The Peptide Evidence Index

Best peptides, ranked by evidence

Here best means most backed by human trials, not most sold. Of 4,970 studies indexed across 28 peptides, only 14% is human evidence — 27% is animal or in-vitro. This page ranks every peptide by that share.

Studies indexed
4,970
Human evidence
14%
Preclinical
27%
Peptides ranked
28

The evidence, all peptides combined

  • Human RCT 3%
  • Human trial 11%
  • Review 32%
  • Animal 16%
  • In-vitro 11%
  • Unknown 28%

The ranking

Sorted by human-evidence share, strongest first. Search demand shown for context.

# Peptide Searches/mo Human Preclinical Top grade
1 Thymosin Alpha-1 1,000 42% 24% Human RCT
2 Survodutide 5,800 32% 20% Human RCT
3 Tesamorelin 58,000 25% 14% Human RCT
4 Tirzepatide 716,000 23% 6% Human RCT
5 Semaglutide 536,000 20% 13% Human RCT
6 Melanotan 1 150 20% 18% Human RCT
7 Pinealon 4,700 17% 62% Animal
8 Ibutamoren 17,000 15% 31% Human RCT
9 AOD-9604 3,500 14% 37% Human trial
10 Cagrilintide 21,000 13% 26% Human RCT
11 Kisspeptin 3,700 12% 59% Human trial
12 PT-141 6,100 11% 14% Human RCT
13 Retatrutide high demand, low evidence 314,000 9% 16% Human RCT
14 MOTS-c high demand, low evidence 20,000 9% 27% Preclinical
15 Ipamorelin high demand, low evidence 30,000 8% 34% Preclinical
16 Semax high demand, low evidence 10,000 8% 58% Preclinical
17 Selank 4,300 8% 60% Preclinical
18 GHK-Cu high demand, low evidence 13,000 6% 48% Preclinical
19 Gonadorelin 5,900 6% 51% Human trial
20 Epitalon 3,300 6% 51% Preclinical
21 CJC-1295 9,500 4% 31% Preclinical
22 Sermorelin high demand, low evidence 117,000 3% 19% Human trial
23 BPC-157 high demand, low evidence 47,000 2% 30% Animal
24 DSIP 5,000 2% 52% Preclinical
25 KPV 1,700 2% 52% Preclinical
26 Humanin 600 2% 28% Preclinical
27 TB-500 5,800 1% 42% Preclinical
28 5-Amino-1MQ 5,000 0% 100% Animal

By goal

Same ranking, filtered to what people actually search for: best peptides for muscle growth , best peptides for weight loss , best peptides for healing .

The hype gap

7 peptides draw 551,000 searches a month between them, yet each has under 10% human evidence in the indexed corpus. The most searched is Retatrutide (9% human) , Sermorelin (3% human) , BPC-157 (2% human) . Popularity is not evidence — see how we grade evidence for what each level means.

How to read this

Each share is computed from the studies this site has indexed for a molecule, graded by their strongest design (human RCT down to in-vitro). Study-level grading is automated, so the per-molecule figures reflect the indexed corpus — weighted toward recent literature — not a molecule's entire history: an older approved analog can show a low human share if its recent indexed studies are reviews. The combined 14% human figure is robust. Full method on our methodology page. Research information only, not medical advice.

Frequently asked questions

What are the best peptides by evidence?
Ranked by human evidence, the peptides with the strongest human-trial backing are approved drugs such as Thymosin Alpha-1 and Survodutide. Across 28 peptides and 4970 indexed studies, only 14% of the evidence is human.
Are peptides safe?
Safety in humans is not established for most research peptides: 27% of the indexed evidence is preclinical (animal or in-vitro) and only 14% is human. This is research information, not medical advice.
Do peptides work?
It depends on the molecule. A few have human randomized-trial evidence; many popular research peptides are supported mainly by animal and in-vitro studies. The ranking above shows the human-evidence share for each.

Search demand captured · evidence corpus refreshed weekly · sourced to primary documents